Nephpros
Platform AI Tools Publication Live Demo Trial Network Comparison About
Request Access →
The Platform

Everything a Nephrology
Research Lab Needs.

Seven layers. Every feature built specifically for kidney disease research. No configuration. Opens in any browser on any device.

Clinical Research
Patient registry · Visit timeline · CKD auto-staging · KFRE risk · 14 biomarker fields · Drug-eGFR interactions · Cohort builder · 6 analytics tabs · Kaplan-Meier · Power calculator · Bonferroni + FDR
Preclinical Module
8 disease models · Time series · Dose-response curves · Organ weights · Histology scoring · Inter-rater reliability (ICC + kappa) · Sample size calculator · 14 analysis tabs · Preclinical AI Analysis
AI Research Assistant
Trajectory forecasting · Trial eligibility screening · Hypothesis generation · Natural language cohort querying · Translational pattern recognition · Clinical note extraction · Biomarker signature clustering
Publication Studio
Figure Studio · Peer Review Tool · Paper Compass · Literature Synthesizer · Full Draft Generator · Abstract Generator · Cover Letter · Poster Maker · Journal Matcher · Manuscript Verifier · STROBE / CONSORT / ARRIVE / PRISMA
AI Research Chat
Cohort-aware multi-turn AI · Knows your patient count, biomarker values, CKD staging, and animal studies · Deep nephrology expertise · Export sessions to Lab Notebook
Lab Notebook
Auto-captures every action · AI daily narrative · Manual annotations · Timeline by date · Filter by event type · Export for IRB submission
Trial Network
Privacy-preserving pharma marketplace · Local browser matching · Aggregate-only data transmission · Sponsor dashboard · Site interest registration
De-identification
HIPAA Safe Harbor method · Replaces 18 identifiers with study codes · AI cleans notes and dates · Downloadable de-ID log · Runs at point of upload before data enters platform
Data Input & Infrastructure
CSV · XLSX · PDF · DOCX · Images · No column naming required · Cross-device login via Supabase · Command palette (Cmd+K) · Access code system · Full audit log · 21 CFR Part 11
Collaboration & Governance
Labs & lab members · Cross-lab access requests · Team activity feed · Threaded comments · Study locks · Automatic version history · Guided onboarding · In-app NEPHPROS Support
Layer 01Clinical Research Platform
Clinical data management built for kidney disease.

Upload cohort data in any file format — CSV, Excel, PDF, DOCX, or images of lab reports. No column naming required. AI reads any structure and extracts the data automatically. Built-in HIPAA Safe Harbor de-identification engine replaces patient identifiers with study codes at the point of upload before any data enters the platform.

01
Patient Registry
CSV, JSON, PDF upload with auto-parse. CKD auto-staging. 14 biomarker fields. Disease-specific intelligence. Role-based ID redaction.
02
Visit Timeline
Unlimited longitudinal visits per patient. Stage-drop alerts. eGFR trajectory tracking. Medication change detection across visits.
03
Biomarker Intelligence
KFRE 5-year kidney failure risk on every patient. Reference range compliance across 8 biomarkers. Drug-eGFR interaction detection for 6 medication classes.
04
Clinical Analytics
Six-tab suite: summary, disease breakdown, distributions, configurable scatter with live Pearson r, correlation heatmap, cohort builder.
05
Advanced Statistics
Kaplan-Meier survival curves with log-rank test. Power calculator with cohort SD auto-population. Simultaneous Bonferroni and FDR correction.
06
Preclinical Module
Eight kidney disease rodent models. Survival analysis, dose-response curve fitting, organ weight tracking, histology scoring, inter-rater reliability, and sample size calculation — all in one place.
Layer 01bPreclinical Research Platform
The most complete preclinical nephrology research platform ever built.

Eight kidney disease rodent models. Fourteen analysis modules. And a first-of-its-kind unified AI engine — the Preclinical AI Analysis — that runs eight simultaneous analyses on your animal data and returns a complete intelligence report in under 30 seconds.

01
8 Disease Models
STZ-DKD · 5/6 Nephrectomy · Thy1.1 IgAN · MRL/lpr Lupus · Adriamycin FSGS · PCK ADPKD · db/db DKD · DOCA-Salt. Each model understood natively.
02
Survival Analysis
Kaplan-Meier curves for animal studies with log-rank testing. Time-to-endpoint analysis. Median survival per group. Publication-ready SVG figures.
03
Dose-Response Curves
4-parameter logistic curve fitting. EC50 estimation with reference lines. Dose-response data table with percent change from baseline. Built for pharmacology.
04
Organ Weights
Kidney weight, body weight, and kidney-to-body-weight ratio tracking. Auto-populates from CSV. Manual terminal entry form. Box plots by group.
05
Histology Scoring
Structured entry for glomerulosclerosis, tubular injury, interstitial fibrosis, and mesangial expansion scores. Group summary table with severity color coding.
06
Inter-Rater Reliability
ICC and Cohen's kappa calculated simultaneously from paired pathologist scores. Interpreted automatically against published benchmarks.
07
Sample Size Calculator
Pre-loaded with typical variance parameters for all 8 disease models. Auto-fills SD from your actual data. Calculates 80%, 90%, and 95% power with Bonferroni correction.
AI
Preclinical AI Analysis
One button. Eight AI analyses simultaneously: responder phenotyping, translational validity scoring, trajectory archetypes, mechanism prediction, optimal timepoints, FDA dose scaling, synthetic control assessment, and a complete publication-ready methods section.
Layer 02AI Research Assistant
Ten instruments. Weeks of work in seconds.

Not a chatbot. Nine purpose-built analytical instruments that operate on your actual cohort data and preclinical studies — performing workflows that previously required days of manual effort or dedicated data science expertise. Plus the Preclinical AI Analysis engine — eight simultaneous AI analyses on your animal data in one report.

Patient Trajectory Forecasting  ·  Trial Eligibility Screening  ·  Hypothesis Generation from Biomarker Correlations  ·  Natural Language Cohort Querying  ·  Cross-Study Translational Pattern Recognition  ·  Clinical Note Extraction  ·  Unsupervised Biomarker Signature Clustering  ·  Drug Repurposing Intelligence  ·  ClinicalTrials.gov Live Feed  ·  Preclinical AI Analysis (8 modules)
Layer 03Clinical Trial Matching Network
Connect sponsors with sites. Without exposing patient data.

A two-sided marketplace connecting pharmaceutical sponsors with kidney disease research sites. Sponsors post structured eligibility criteria. Researchers screen their local cohorts — patient records never leave the researcher's system.

Privacy Architecture: All eligibility matching runs locally within each researcher's browser. Only site name, PI email, and an aggregate patient count cross the site-to-sponsor boundary. No patient identifiers. No clinical records. No exceptions.
Layer 04Publication Studio
From raw data to published paper. End-to-end.

The only research platform with a complete publishing workflow built in. Five integrated tools that take a researcher from data to submitted manuscript — without leaving Nephpros. See the full Publication Studio for details.

01
Figure Studio
Upload any data file. AI generates a publication-ready SVG figure automatically — bar charts, scatter plots, KM curves, heatmaps, forest plots, volcano plots. Journal-specific formatting for JASN, AJKD, KI, Nature Medicine, NEJM, JAMA, Lancet. SVG and PNG download.
02
Peer Review Tool
Upload any manuscript. AI performs a full structured peer review — major concerns, minor concerns, statistical audit, methods evaluation, clinical plausibility check, and recommendation. Also drafts point-by-point rebuttal responses using your actual cohort data.
03
Paper Generator
Six tools: Paper Compass identifies every publishable paper in your data. Literature Synthesizer maps the field from uploaded references. Outline Builder, Full Draft Generator (~3,500 words from your actual numbers), Abstract Generator, and Cover Letter Writer — all journal-specific.
04
Poster Maker
Generate a complete A0 conference poster from your loaded data, from an uploaded paper, or from custom content. Three color schemes. AI layouts the poster with embedded data visualizations. SVG download for infinite-resolution printing.
05
Submission Tools
Journal Matcher ranks the top 5 journals for your paper. Reporting Checklist verifies against STROBE, CONSORT, ARRIVE, PRISMA, CARE, or TRIPOD. Manuscript Verifier checks every reported number against your actual loaded data. Author Contributions generator uses CRediT taxonomy.
Layer 05AI Research Chat
A collaborator that knows your data.

Not a generic chatbot. A nephrology-specialized AI research assistant with full awareness of your loaded cohort — patient count, disease distribution, biomarker values, CKD staging, animal studies, everything. Ask anything about your research, methodology, statistics, grant strategy, or clinical interpretation. It answers specifically about your data, not in generalities.

01
Cohort-Aware Responses
Every response is grounded in your actual loaded data. Ask "what are the strongest correlations in my cohort?" and get a specific answer — not a generic explanation of what correlations are.
02
Multi-Turn Memory
Remembers the full conversation within each session. Build on previous questions, refine hypotheses, work through complex methodological decisions over multiple exchanges.
03
Deep Nephrology Expertise
Expert-level knowledge of all 10 kidney disease types, KDIGO guidelines, biomarker interpretation, biostatistics, grant writing, and academic publishing — embedded in every response.
04
Save to Lab Notebook
Any conversation can be exported to the Lab Notebook with one click — creating a permanent record of the research thinking and AI-assisted decisions made during a session.
Layer 06Lab Notebook
Every experiment. Every insight. Captured automatically.

A complete auto-generated research journal. Every upload, analysis, AI interaction, figure generation, and platform event is timestamped and recorded without any researcher input. Combined with AI-written daily narratives, Nephpros creates the lab notebook that researchers used to spend hours writing by hand.

01
Automatic Capture
Every action logged: data uploads with record counts, AI tool runs with outputs, figure exports, preclinical analyses, chat sessions, login and logout events. Zero manual input required.
02
AI Daily Narrative
One click generates an AI-written professional narrative of the day's research activity — written in formal past tense, third person, the way a real lab notebook should read. IRB and grant-reviewer ready.
03
Manual Annotations
Add free-text notes, observations, hypotheses, and decisions alongside automatic entries. Everything timestamped and attributed to the researcher who wrote it.
04
Timeline & Export
Full timeline view grouped by date. Filter by event type. Export complete notebook as text file for IRB submission, grant appendix, or institutional record-keeping.
Layer 07Collaboration & Governance
Built for teams. Governed like a regulated system.

Nephpros isn't a single-user tool. Multiple researchers can share a lab, request access to each other's cohorts, and follow a live feed of what's happening across the team — while every study stays locked, versioned, and auditable.

01
Labs & Lab Members
Invite colleagues into a shared lab workspace. One institution, one shared research environment — instead of scattered spreadsheets and email attachments.
02
Cross-Lab Access Requests
Request access to another lab's cohort for collaboration or multi-site studies. Owners approve or deny explicitly — nothing is shared automatically.
03
Team Activity Feed
A live, lab-wide feed of uploads, analyses, AI tool runs, and comments — so every collaborator knows what changed and when, without asking.
04
Threaded Comments
Discuss a patient record, dataset, or finding directly where the work happened, with full comment threads — instead of context lost in email.
05
Study Locks
Lock a study to freeze its data and analyses before sharing, publishing, or submitting for review — preventing silent changes after the fact.
06
Automatic Version History
Every locked study keeps a full version history, so past states can be reviewed or restored — not just an audit log, but the actual underlying data.
Getting started is guided, not googled: new researchers get a walkthrough on first login, and can reach NEPHPROS Support — an in-app AI assistant — any time they get stuck.